منابع مشابه
Analysis of temozolomide resistance in lowgrade gliomas by using a mechanistic mathematical model
Understanding how tumours develop resistance to chemotherapy is a major issue in oncology. When treated with temozolomide (TMZ), an oral alkylating chemotherapy drug, most low-grade gliomas (LGG) show an initial volume decrease but this effect is rarely long lasting. In addition, it has been suggested that TMZ may drive tumour progression in a subset of patients as a result of acquired resistan...
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1 Medical Oncology 1, Veneto Institute of Oncology-IRCCS, Via Gattamelata 64, 35128 Padua, Italy 2 Neurosurgery Department, Padua Hospital, 35128 Padua, Italy 3 Department of Neuro-Oncology, UPMC, GH Pitié-Salpétrière, 75005 Paris, France 4DBBS, National Neurological Institute C. Mondino, University of Pavia, 27100 Pavia, Italy 5 Neurology Unit, National Cancer Unit, Regina Elena, 00144 Rome, I...
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The term oligodendroglioma was created by Bailey, Cushing, and Bucy based on the observation that these tumors share morphological similarities with oligodendrocytes (Bailey and Cushing 1926; Bailey and Bucy 1929). However, a convincing link between oligodendrocytes and oligodendrogliomas still needs to be shown. Oligoastrocytomas or mixed gliomas are histologically defined by the presence of o...
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Diffuse intrinsic pontine glioma (DIPG) is the most common type representing approximate‐ ly 80% of brainstem gliomas [5, 6]. They have a dismal prognosis with a median survival of only a year. Their natural history is often compared to but worse than that of supratentorial glioblastoma seen primarily in the adult population. Nondiffuse brainstem gliomas, includ‐ ing focal, dorsal exophytic and...
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The present retrospective study was designed to analyze factors with prognostic values a) within, and b) significantly associated with, short-term (12months or less) and long-term (more than 24 months) survival times, i n 72 consecutive patients treated for malignant gliomas. Among 41 (57%) short-term surviving patients, the absence of both aphasia and motor deficit (as initial presenting ...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2014
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2013-0345